Integrated chemical systems on microchips for analysis and assay. Potential future, mobile high-performance detection system for chemical weapons
- 1 January 2002
- journal article
- Published by Walter de Gruyter GmbH in Pure and Applied Chemistry
- Vol. 74 (12) , 2299-2309
- https://doi.org/10.1351/pac200274122299
Abstract
By analogy to unit operations (e.g., mixers, reactors, etc.) used in conventional chemical engineering, the concept of microunit operations permits the integration of complicated chemical systems onto a small microchip. A protocol for fabrication of such microchips is described, and its use is illustrated in several examples. In addition, the thermal lens microscope, which determines nonfluorescent species at the single-molecule level, is indispensable as an ultrasensitive detector for general use. Applications of microchip technology are given for chemical analysis, immunoassay, and full bioassay. Microchip analysis can provide very large enhancements in sensitivity and substantial reductions in measurement time as compared with conventional analytical methods.Keywords
This publication has 1 reference indexed in Scilit:
- Use of a thermal lens microscope in integrated catecholamine determination on a microchipAnalytical and Bioanalytical Chemistry, 2001