“Central” commissurotomy for intractable generalized epilepsy

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Abstract
A second consecutive series of 12 patients underwent microsurgical “central” commissurotomy (division of the entire corpus callosum and hippocampal commissure) for the relief of previously intractable generalized seizures. This modified operation was found to be safer than the multiple commissurotomies performed in the first series of eight patients and was equally effective. Central commissurotomy was modified further by being performed in two stages, which reduced the length and severity of the “acute disconnection syndrome,” a common cause of morbidity in the early postoperative phase.