Activities of the Mitochondrial NAD-Linked Isocitric Dehydrogenase in Different Regions of the Rat Brain

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Abstract
Specific activities of NAD-linked isocitric dehydrogenase were determined in hypothalamus, cerebellum, pons and medulla, striatum, midbrain and cerebral cortex (which included the hippocampus) of the female Wistar rat. In aging the specific activities of this enzyme were decreased in all regions. Chronic treatment with manganese chloride from conception onward for a period of over 2 yr appeared to counteract these decreases during aging. Mn had no apparent effect on the specific activities of this enzyme in different brain regions of 2-mo.-old animals.