This chapter introduces the reader to the signs and symptoms of people who suffer from mood episodes highlighting the medications and treatment for the most common types of bipolar disorder. To highlight the primary disorders, information related to the following diagnostic categories in the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) is presented: Bipolar I Disorder, Bipolar II Disorder, Cyclothymic Disorder, Substance/Medication-Induced Bipolar and Related Disorder, Bipolar and Related Disorder Due to Another Medical Condition, Other Specified Bipolar and Related Disorders, and Unspecified Bipolar and Related Disorder. The chapter reviews the basics of these diagnoses and the medications and supportive treatments used to assist clients. This awareness is used to help empower clients to become active participants in their own treatment. Social work can play an important role in treating and assisting clients who suffer from these disorders, along with helping their support systems.