Genetic Control of Drug Levels in Man: Phenylbutazone

29 March 1968

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 159 (3822) , 1479-1480
https://doi.org/10.1126/science.159.3822.1479

Abstract

Phenylbutazone was administered to seven pairs of identical (monozygotic) twins and to seven pairs of fraternal (dizygotic) twins. Individual half-lives ranged from 1.2 to 7.3 days. Subjects with identical genotypes (monozygotic twins) exhibited very similar phenylbutazone half-lives; significantly greater differences in half-life occurred in dizygotic twins. The previously established large variations among individuals in phenylbutazone metabolism appear to be genetically, rather than environmentally, determined.

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