THE EFFECT OF VITAMINS OF THE B COMPLEX ON THE WORK OUTPUT OF PERFUSED FROG MUSCLES

Publisher Website
Google Scholar
Abstract
Fatigue curves were graphically recorded for each gastrocnemius muscle of a frog under uniform conditions of perfusion, loading, and stimulation. For each animal, a fatigue curve was obtained from one gastrocnemius, while perfused through the general circulation with a BHCO3-CO2 buffered glucose-Ringers soln. Vits. of the B complex were then added to the perfusing fluid, and a fatigue curve recorded for the other gastrocnemius. Conc. of 0.01 mM/l. of each of the following vits. were tested; thiamine, pantothenic acid, pyridoxine, nicotinic acid amide, and riboflavine. Ten ani-mals were tested with each vitamin. Statistically significant improvement in avg. work output of the second leg waa observed with pantothenic acid and thiamine. Pyridoxine and nicotinic acid amide produced some improvement, but the results were not statistically significant. No improvement in work output was obtained with riboflavine.