A COMPARISON OF SOME CARDIORESPIRATORY EFFECTS OF ALTHESIN AND KETAMINE WHEN USED FOR INDUCTION OF ANAESTHESIA IN PATIENTS WITH CARDIAC DISEASE
- 1 November 1976
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 48 (11) , 1071-1081
- https://doi.org/10.1093/bja/48.11.1071
Abstract
Cardiorespiratory effects of ketamine and Althesin were measured in 2 groups of premedicated patients with cardiac disease. The drugs were given in clinically equivalent doses with a 2nd dose administered about 10 min after induction. The 1st dose of ketamine caused a marked increase in systemic and pulmonary arterial pressure, heart rate and central venous and wedge pressures and cardiac index. The 1st dose of Althesin caused a decrease in systemic arterial pressure, central venous pressure, cardiac index and heart work, but little change in heart rate. The 2nd dose of induction agent was administered before the cardiorespiratory effects of the initial dose had resolved. The 2nd dose of Althesin caused changes similar to those following the 1st dose, but less marked. The changes following the 2nd dose of ketamine were opposite to those following the 1st dose.This publication has 2 references indexed in Scilit:
- Measurement of cardiac output by thermal dilution in man.Journal of Applied Physiology, 1968
- Nomograms for correction of blood Po2, Pco2, pH, and base excess for time and temperature.Journal of Applied Physiology, 1966