Liberation of Histamine and Heparin by Peptone from the Isolated Dog's Liver.

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Abstract
The injn. of peptone into the isolated dog''s liver does not release significant amts. of heparin and histamine when Tyrode''s soln. is used for perfusion. With heparinized blood, some heparin and histamine were released by peptone. Blood was obtained for the perfusion without the use of anticoagulants by coating cannulae, glassware, etc., with Dri-Film 9987 (General Electric Co.). The addition of peptone to this blood resulted in the release of very large amts. of histamine and heparin by the liver, suggesting that changes in the blood were important factors in the action of peptone on the liver. Hematologic studies showed a marked decrease in the platelet count of blood with peptone after passing through the liver and that the addition of peptone caused agglutination of platelets. Smears from the liver showed the clumps of agglutinated platelets in the liver.

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