Micronucleus Formation in Preimplanted Mouse Embryos CulturedIn Vitroafter Irradiation with X-rays and Neutrons
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 39 (3) , 307-314
- https://doi.org/10.1080/09553008114550391
Abstract
Preimplanted mouse embryos cultured in vitro were irradiated with X-rays and neutrons in the late G2-phase of the 2-cell stage. Both radiation qualities induced micronuclei at very low doses. The kinetics of micronucleus formation during the first and second cell cycles after X-irradiation depended on the radiation dose and on the extent of the division delay. New micronuclei appeared to be formed even after the third and later post-irradiation mitoses. The shape of the various dose-effect curves and the mechanism of micronucleus formation by the two radiation qualities are discussed.This publication has 13 references indexed in Scilit:
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