Infection of Tissue Culture Cells with Bloodstream Trypomastigotes of Trypanosoma cruzi

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Abstract
Infection of tissue culture (Vero [African green monkey kidney cell] and bovine embryo skeletal muscle cells) with bloodstream forms of T. cruzi depends on an adequate serum concentration and a suitable parasite population. The percentages of infections of Vero cells obtained with inocula presenting about 90% (Y strain) and 2% (CL strain) of slender trypomastigotes were 11.8 .+-. 4.9% and 0.1%, respectively, strongly indicating that the presence of slender forms was essential for cell infection to occur. Other biological characteristics seem to influence the infectivity of bloodstream stages because evidence was provided that slender forms of the CL strain were less infective to Vero and muscle cells than slender forms of the Y strain.

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