Genome maintenance mechanisms for preventing cancer
Top Cited Papers
- 1 May 2001
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 411 (6835) , 366-374
- https://doi.org/10.1038/35077232
Abstract
The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing oncogenesis. During the past decade, knowledge about the mechanisms by which genes erode and the molecular machinery designed to counteract this time-dependent genetic degeneration has increased markedly. At the same time, it has become apparent that inherited or acquired deficiencies in genome maintenance systems contribute significantly to the onset of cancer. This review summarizes the main DNA caretaking systems and their impact on genome stability and carcinogenesis.Keywords
This publication has 63 references indexed in Scilit:
- Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair ProteinPublished by Elsevier ,2001
- DNA MISMATCH REPAIR AND GENETIC INSTABILITYAnnual Review of Genetics, 2000
- Partners and pathwaysTrends in Genetics, 2000
- RETRACTED: Transcription-Coupled Repair of 8-oxoGuanine: Requirement for XPG, TFIIH, and CSB and Implications for Cockayne SyndromeCell, 2000
- Mouse models for colorectal cancerOncogene, 1999
- Action of DNA Repair Endonuclease ERCC1/XPF in Living CellsScience, 1999
- ATM: from gene to functionHuman Molecular Genetics, 1998
- A survey of telomerase activity in human cancerPublished by Elsevier ,1997
- The RAD6 DNA repair pathway in Saccharomyces cerevisiae: What does it do, and how does it do it?BioEssays, 1994
- Instability and decay of the primary structure of DNANature, 1993