Structure‐Based Design of Potent Beta‐Lactamase Inhibitors
- 4 March 1998
- book chapter
- Published by Wiley
Abstract
No abstract availableKeywords
This publication has 16 references indexed in Scilit:
- Design, Synthesis, and Evaluation of 2β-Alkenyl Penam Sulfone Acids as Inhibitors of β-LactamasesJournal of Medicinal Chemistry, 1996
- Production of a plasmid mediated AmpC-like β-lactamase by a Klebsiella pneumoniae septicaemia isolateJournal of Antimicrobial Chemotherapy, 1994
- The Role of Tyrosine 150 in Catalysis of .beta.-Lactam Hydrolysis by AmpC .beta.-Lactamase from Escherichia coli Investigated by Site-Directed MutagenesisBiochemistry, 1994
- Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolutionNature, 1992
- Preferential hydrolysis of cis configuration compounds at the 3,4 position of monobactams by beta-lactamase from Morganella morganiiAntimicrobial Agents and Chemotherapy, 1991
- Refined crystal structure of β-lactamase from Citrobacter freundiiindicates a mechanism for β-lactam hydrolysisNature, 1990
- Bacterial Resistance to β-Lactam Antibiotics: Crystal Structure of β-Lactamase from Staphylococcus aureus PC1 at 2.5 Å ResolutionScience, 1987
- Evaluation of Intrinsic Binding Energy from a Hydrogen Bonding Group in an Enzyme InhibitorScience, 1987
- α-Chymotrypsin: A Case Study of Substituent Constants and Regression Analysis in Enzymic Structure—Activity RelationshipsJournal of Pharmaceutical Sciences, 1970