Hypocholesterolemic Activity of Phytosterol.

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Abstract
The hypocholesterolemic activity of phytosterol was studied using rats on a 3%-cholesterol containing diet. Rats were i.v. injected for 5 days with emulsion of saline-albumin containing phytosterol and the plasma and liver cholesterol level was decreased. The decreasing in liver cholesterol level was accompanied by an increase of bile acid contents excretion without change in composition, and the injected phytosterol was accumulated in liver mainly. The cholesterol level in liver subcellular fractions after phytosterol treatment was decreased most significantly in soluble fraction, but little or not in microsome, although most of phytosterol in the liver cells was distributed in this fraction. These results suggest that the absorbed phytosterol has the ability to decrease the cholesterol level in liver by means of the enhancement of conversion from cholesterol to bile acid.

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