GLUCOSE HOMEOSTASIS FOLLOWING INJURY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 61  (6) , 427-434
Abstract
This paper records and quantitates the extent of hyperglycemia in patients undergoing surgery of different degrees of severity and relates them to changes in blood insulin, growth hormone, cortisol and catecholamine concentrations. Further animal studies were performed which suggested that a fall in intracellular glucose utilization may be a contributory factor. The use of isotope labeling of glucose in man has enabled further studies to be done to clarify changes in exchangeable glucose mass, replacement rate and space, both in the normal situation and in the presence of infusions of glucagon, noradrenaline [norepinephrine], glucose and amino acids. The hyperglycemia is clearly the result of a complex interaction of changes in the availability and activity of hormones which control glucose metabolism both within and outside the cell.