RED BLOOD-CELL SELECTION IN CHIMERIC MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 5  (1) , 1-7
Abstract
Starch gel electrophoresis of a large number of tissues and organs from C3H .tautm. C57BL aggregation chimeras [Mus musculus] suggests that the C57BL red blood cell population predominates, but for other tissues the proportions of the 2 components are more nearly equal. A similar predominance of (C57BL .times. C3H)F1 red blood cells is seen in (C57BL .times. C3H)F1 .tautm. recessive chimeras. Analysis of blood samples taken from the same animals at different times suggests that a temporal shift in the proportions of the 2 component red cell populations occurs in some adult chimeras and results in an unbalanced chimeric phenotype. Differential mitotic activity apparently contributes to strain-dependent, tissue-specific selection pressures in the erythropoietic tissue.

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