PULMONARY MORPHOLOGY IN A MULTI-HOSPITAL COLLABORATIVE EXTRACORPOREAL MEMBRANE-OXYGENATION PROJECT .1. LIGHT-MICROSCOPY
- 1 January 1979
- journal article
- research article
- Vol. 95 (1) , 191-214
Abstract
The light microscopic morphology found at autopsy in 59 patients who participated in an organized controlled trial of extracorporeal oxygenation as therapy for acute respiratory failure was studied. Observations were recorded as objectively as possible and were analyzed by computer. The experimental therapy produced no specific alteration in the observed pulmonary lesions. Many of the lesions tabulated had significant correlation coefficients with time, all of which were higher when correlated with the duration of respiratory failure than with the duration of the entire acute illness. The rapid progression of the lesions to fibrosis is emphasized as is the predilection of both early and late lesions to involve alveolar ducts to a far greater degree than the distal alveolar spaces. The lesions may result as much from O2 damage as from the original acute illness.This publication has 22 references indexed in Scilit:
- Tolerance and cross-tolerance using NO2 and O2. I. Toxicology and biochemistryJournal of Applied Physiology, 1978
- Alterations of the Gas Exchange Apparatus in Adult Respiratory Insufficiency Associated with Septicemia1,2American Review of Respiratory Disease, 1977
- Twelve Years' Experience With Bronchopulmonary DysplasiaPediatrics, 1977
- Diffuse alveolar damage--the role of oxygen, shock, and related factors. A review.1976
- The Core Pathobiology and Integrated Medical Science of Adult Acute Respiratory InsufficiencySurgical Clinics of North America, 1976
- Cross-linking of cold-insoluble globulin by fibrin-stabilizing factorJournal of Biological Chemistry, 1975
- Oxygen pneumonitis in man. Ultrastructural observations on the development of alveolar lesions.1972
- Ozone ToxicologyArchives of environmental health, 1965
- HISTOPATHOLOGY OF EXPOSURE TO PHOSGENE - ATTEMPT TO PRODUCE PULMONARY EMPHYSEMA EXPERIMENTALLY1964
- Ventilation of terminal air unitsJournal of Applied Physiology, 1962