The Effects of Griseofulvin on Diploid Strains of Coprinus lagopus

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Abstract
Diploid strains of C. lagopus grown on medium supplemented with griseofulvin (20 .mu.g ml-1) produced fast-growing sectors of 2 types after 7-28 days incubation; these were diploid somatic recombinants and haploids. A dikaryon grown on the same medium broke down to give 1 haploid component only; resolution of this dikaryon and a near-isogenic diploid resulted in selection for sectors carrying a gene for resistance to griseofulvin. The use of this antibiotic is suggested as a tool for routine haploidization in C. lagopus.