Regulation of Bone Formation and Vision byLRP5

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Abstract
Osteoporosis affects several million people and is associated with medical costs of up to $15 billion per year in the United States alone.1,2 Thus, identifying the molecular mechanisms that control bone mass is a task of the utmost importance. The recent identification of the role of the low-density lipoprotein receptor–related protein 5 (LRP5) gene in the regulation of bone mass is a landmark discovery.36 We examine the lock-and-key mechanism involving LRP5 that regulates two different functions: bone formation and vision.The LockThe low-density lipoprotein receptor–related proteins are a family of cell-surface receptors involved in diverse biologic processes, . . .