Bile Salt Malabsorption in the Radiation Syndrome
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Acta Radiologica: Oncology, Radiation, Physics, Biology
- Vol. 17 (4) , 312-318
- https://doi.org/10.3109/02841867809127934
Abstract
The fraction of faecal activity (FBS) excreted after intravenous administration of 14C-labelled cholic acid was measured in 20 patients with gastrointestinal symptoms (diarrhoea, abdominal pains, malabsorption and rectal haemorrhage) after pelvic irradiation. An FBS excretion of 52 +/- 16 per cent (mean +/- SD) was found in 13 patients with diarrhoea and 18 +/- 12 per cent in 7 patients without diarrhoea. In normals the excretion is not above 18 per cent. Bile salt malabsorption appears to be an important factor in the pathogenesis of diarrhoea in these patients.Keywords
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