The androgenic control of the composition of the rat epididymis determined by efferent duct ligation or castration

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Abstract
The technique of efferent duct ligation prevents spermatozoa from entering the epididymis and enables metabolic processes to be studied in the androgen-maintained epididymis without contribution from spermatozoa. Castration enables the epididymis to be studied when spermatozoa and androgenic support are absent. [Weight, total protein, phospholipid, DNA, RNA, acid soluble P, glycogen and sialic acid were studied in both procedures.] The alterations in biochemical composition reported supplemental anatomical studies in indicating that the androgen-deprived epididymis is an involuted organ which probably has a markedly reduced synthetic activity.

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