Enhanced vasoconstrictor effect of endothelin in cerebral arteries from rats with subarachnoid haemorrhage
- 1 March 1990
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 138 (3) , 317-319
- https://doi.org/10.1111/j.1748-1716.1990.tb08852.x
Abstract
The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline-injected controls. Endothelin elicited concentration-dependent contractions of rat basilar artery segments. The endothelin-induced contractions were much stronger in the SAH compared to control animals, which suggests a role in the pathophysiology of cerebral vasospasm.Keywords
This publication has 7 references indexed in Scilit:
- Mechanisms of Action of Endothelin on Isolated Feline Cerebral Arteries: In vitro Pharmacology and ElectrophysiologyJournal of Cerebral Blood Flow & Metabolism, 1989
- Effects of endothelin on the renal artery from spontaneously hypertensive and Wistar Kyoto ratsEuropean Journal of Pharmacology, 1988
- Alterations in endothelium-dependent responsiveness of the canine basilar artery after subarachnoid hemorrhageJournal of Neurosurgery, 1988
- Therapeutic Trial of Intravenous Nimodipine in Patients with Established Cerebral Vasospasm after Rupture of Intracranial AneurysmsNeurosurgery, 1988
- Therapeutic trial of intravenous nimodipine in patients with established cerebral vasospasm after rupture of intracranial aneurysmsNeurosurgery, 1988
- A novel potent vasoconstrictor peptide produced by vascular endothelial cellsNature, 1988
- Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries.Stroke, 1985