Synthesis, in vitro validation and in vivo pharmacokinetics of [125I]N-[2-(4-Iodophenyl)Ethyl]-N-Methyl-2-(1-Piperidinyl) ethylamine: A high-affinity ligand for imaging sigma receptor positive tumors
- 31 August 1996
- journal article
- Published by Elsevier in Nuclear Medicine and Biology
- Vol. 23 (6) , 761-766
- https://doi.org/10.1016/0969-8051(96)00070-4
Abstract
No abstract availableKeywords
This publication has 14 references indexed in Scilit:
- σ Binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in cultureEuropean Journal of Pharmacology, 1995
- Sigma receptors are expressed in human non-small cell lung carcinomaLife Sciences, 1995
- Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labelingEuropean Journal of Pharmacology: Molecular Pharmacology, 1994
- Synthesis and Characterization of [125I]-N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide, a New .sigma. Receptor Radiopharmaceutical: High-Affinity Binding to MCF-7 Breast Tumor CellsJournal of Medicinal Chemistry, 1994
- Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patientsEuropean Journal of Nuclear Medicine and Molecular Imaging, 1993
- Synthesis and binding characteristics of potential SPECT imaging agents for .sigma.-1 and .sigma.-2 binding sitesJournal of Medicinal Chemistry, 1993
- An improved synthesis of [125I]N-(diethylaminoethyl)-4-iodobenzamide: a potential ligand for imaging malignant melanomaNuclear Medicine and Biology, 1993
- Synthesis and receptor binding properties of fluoro- and iodo-substituted high-affinity .sigma.-receptor ligands: identification of potential PET and SPECT .sigma.-receptor imaging agentsJournal of Medicinal Chemistry, 1992
- Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the .sigma. receptorJournal of Medicinal Chemistry, 1992
- A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brainBrain Research, 1990