Heme and Globin Synthesis Control: Observations in vivo in Beta Thalassemia
- 3 March 1967
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 155 (3766) , 1116-1118
- https://doi.org/10.1126/science.155.3766.1116
Abstract
After administration of glycine-2- 14 C to a patient with thalassemia, the specific activities of heme and globin of F hemoglobin were consistently higher than those of hemoglobin A. After reaching a maximum, the ratio of the specific activity of heme to that of globin remained constant within each hemoglobin. Explanations considered include dilution by preformed subunits, differential turnover of hemoglobins, and possibly more than one heme-synthesizing pool.Keywords
This publication has 18 references indexed in Scilit:
- Protein synthesis in a cell free human reticulocyte system: ribosome function in thalassemia.Journal of Clinical Investigation, 1966
- Regulation of haemoglobin synthesis at the polysome levelJournal of Molecular Biology, 1966
- Human HaemoglobinsJournal of Medical Genetics, 1965
- The effect of hemin on the synthesis of globinBiochemical and Biophysical Research Communications, 1965
- Hemoglobins A and F: Formation in Thalassemia and Other Hemolytic AnemiasScience, 1964
- Alpha-Chain of Human Hemoglobin: Occurrence in vivoScience, 1964
- THE TURNOVER OF HEMOGLOBINS A, F, AND A2 IN THE PERIPHERAL BLOOD OF THREE PATIENTS WITH THALASSEMIA*Journal of Clinical Investigation, 1963
- Ribosomes Active in Protein Synthesis in Human Reticulocytes : a Defect in Thalassæmia MajorNature, 1963
- Separation of Hemoglobin a and F by Cation Exchange Dextran GelsScandinavian Journal of Clinical and Laboratory Investigation, 1963
- THE SYNTHESIS OF HEME AND GLOBIN IN THE MATURING HUMAN ERYTHROID CELL*Journal of Clinical Investigation, 1961