Magnesium and Ascorbic Acid Supplementation in Diabetes mellitus

Publisher Website
Google Scholar
Abstract
The effect of magnesium (Mg) and ascorbic acid (AA) supplementation on metabolic control was assessed in 56 outpatient diabetics. A 90-day run-in period was followed by two 90-day treatment periods, during which Mg (600 mg/day) and AA (2 g/day) were administered in a randomized double-blind cross-over fashion. A decrease in systolic and diastolic blood pressure (132 ± 3 vs. 138 ± 4 and 77 ± 2 vs. 82 ± 2 mm Hg; p < 0.05) was observed in insulin-dependent diabetes mellitus subjects during Mg supplementation. No beneficial effect of Mg supplementation was observed on glycemic control, lipids or blood pressure in non-insulin-dependent diabetes mellitus (NIDDM) subjects. AA supplementation improved glycemic control among NIDDM subjects and both fasting blood glucose (9.1 ± 0.5 vs. 10.1 ± 0.6 mmol/l; p < 0.05) and HbA1c (8.5 ± 0.3 vs. 9.3 ± 0.3%; p < 0.05) improved. Beneficial effects of AA supplementation on cholesterol (5.9 ± 0.2 vs. 6.2 ± 0.2 mmol/l; p < 0.05) and triglycerides (2.2 ± 0.2 vs. 2.5 ± 0.2; p < 0.05) were also observed in NIDDM subjects. The results suggest that high-dose AA supplementation may have a beneficial effect in NIDDM subjects on both glycemic control and blood lipids.

This publication has 0 references indexed in Scilit: