ACTION OF PENICILLIN ON AEROBACTER CLOACAE

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Abstract
Hugo , W. B. (University of Nottingham, Nottingham, England), and A. D. Russell . Action of penicillin on Aerobacter cloacae . J. Bacteriol. 82: 411–417. 1961.—A study has been made of the action of penicillin on a penicillinase-producing strain of Aerobacter cloacae . It has been found that in culture media rendered hypertonic by the addition of sucrose (0.33 to 0.66 m ), provided a source of magnesium ions is present, cell wall lesions occur, giving rise to osmotically fragile spheroplasts. Evidence is also presented of a lethal effect not associated with cell wall damage. Penicillinase production is not a complete challenge to the action of penicillin and in certain experimental situations renders the cells more susceptible to penicillin action.