STUDIES ON NON-H-2-LINKED LYMPHOCTE-ACTIVATING DETERMINANTS .2. NONEXPRESSION OF MLS DETERMINANTS IN A MOUSE STRAIN WITH AN X-LINKED B LYMPHOCYTE IMMUNE DEFECT

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 117  (5) , 1922-1926
Abstract
Minor lymphocyte-stimulating (Mls) coded non-H-2-linked lymphocyte-activating determinants (LADs) are present on a late developing subpopulation of murine B [bone marrow-derived] lymphocytes. Spleen cells derived from CBA/N mice, a strain with an X-linked defect in B cell function, failed to stimulate a response in Mls-defined mixed lymphocyte reactions (MLRs) with H-2 identical CBA/J or C3H/N responder spleen cells. CBA/J and C3H/N spleen cells induced significant responses in CBA/N responder spleen cells. The inability of CBA/N cells to induce an Mls-defined response was not due to the presence of the nonstimulatory Mlsb genotype, since spleen cells of immunologically normal F1 mice derived from crosses of CBA/N and C3H/N mice were stimulatory in MLRs for C3H/N responder cells. Immunologically abnormal CBA/N .female. .times. C3H/N .male. F1 male mice, which are hemizygous for the CBA/N X chromosome, were also unable to induce a response in Mls-defined MLRs. Although the Mls-coded LADS are not X linked in immunologically normal mouse strains, the failure of CBA/N mice to functionally express the Mls-coded LADs apparently is X linked. This characteristic was not secondary to the presence of suppressor cells and is most likely related to the absence of a late developing (mature) subpopulation of B lymphocytes in these mice.

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