Pharmacokinetics and efficacy of ceftazidime in experimental Haemophilus influenzae b meningitis

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Abstract
Ceftazidime is active in vitro against Haemophilus influenzae . When given to infant rats in a dose of 25 mg/kg ceftazidime achieved a mean peak blood concentration of 31.8 mg/l and a mean trough concentration at 3 h of 2.5 mg/l during steady state. Blood half-life of ceftazidime was 1.3 h. Mean CSF penetration of ceftazidime was 22.8% of blood levels, independent of the presence or absence of meningitis. Infant rats with meningitis due to β -lactamase negative and β -lactamase positive H. influenzae strains had decreased CSF bacterial counts 8 h after a single 25 mg/kg dose and, without additional therapy, 45% of animals maintained negative cultures.

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