Non-random distribution of Alu-family repeats in human chromosomes
- 1 June 1987
- journal article
- research article
- Published by Springer Nature in Molecular Biology Reports
- Vol. 12 (2) , 117-121
- https://doi.org/10.1007/bf00368879
Abstract
A phage lambda recombinant clone containing at least 8 Alu-family repeats (AFRs) has been isolated from a human genomic library, and DNA from the phage was used as a probe for in situ hybridization on G-banded human metaphase chromosomes of healthy donors and leukemic patients. Some chromosome bands show prominent clusters of silver grains in all individuals examined: 1p34, 1q23, 2q21–22, 10p14, 11p14, 10q21 and 11q14. The data suggest non-random distribution of AFRs in the human genome.Keywords
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