Relationship of Substance P‐lmmunoreactive Nerve Fibers with Somatotropes of the Anterior Pituitary in the Monkey

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Abstract
In a previous study, substance P-immunoreactive nerve fibers were demonstrated in the pars distalis of the anterior pituitary in the monkey. The present work investigated their relationship with somatotropes. Pituitaries of Macaca mulatta monkeys were frozen, sectioned and double immunostained with antisera against substance P and human growth hormone. Substance P-immunoreactive nerve fibers, with many varicosities, were found in close proximity to somatotropes. It is suggested that a direct neural factor may be involved in the regulation of growth hormone secretion.