METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 1,4-EPOXY-1,4-DIHYDRONAPHTHALENE IN RATS

Publisher Website
Google Scholar
Abstract
1, 4-Epoxy-l, 4-dihydronaphthalene is converted by rats into 1, 4: 2, 3-diepoxy-l, 2, 3, 4-tetrahydronaphthalene, which was isolated from the urine. The synthesis of the diepoxide is described. The monoepoxide also yielded a compound that is believed to be 1, 4-dihydro-1, 4-dihydroxynaphthalene, but no corresponding mercapturic acid was detected. A number of unidentified metabolites of the monoepoxide were detected that appear to arise by the hydroxylation of the diepoxide. The monoepoxide is converted into the diepoxide by a rat-liver microsomal system. 1, 4-Epoxy-l, 4-dihydronaphthalene does not appear to be an intermediate in naphthalane metabolism.