Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum
- 7 April 2005
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 93 (3) , 762-765
- https://doi.org/10.1111/j.1471-4159.2005.03134.x
Abstract
Precise regulation of dopaminergic activity is of obvious importance for the physiology and pathology of basal ganglia. We report here that nanomolar concentrations of the astrocyte-derived neuroinhibitory metabolite kynurenic acid (KYNA) potently reduce the extracellular levels of striatal dopamine in unanesthetized rats in vivo. This effect, which is initiated by the KYNA-induced blockade of alpha7 nicotinic acetylcholine receptors, highlights the functional relevance of glia-neuron interactions in the striatum and indicates that even modest increases in the brain levels of endogenous KYNA are capable of interfering with dopaminergic neurotransmission.Keywords
This publication has 33 references indexed in Scilit:
- Voltammetric study of the control of striatal dopamine release by glutamateJournal of Neurochemistry, 2004
- Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in MiceMolecular Pharmacology, 2004
- Targeted Deletion of the Kynurenine Aminotransferase II Gene Reveals a Critical Role of Endogenous Kynurenic Acid in the Regulation of Synaptic Transmission viaα7 Nicotinic Receptors in the HippocampusJournal of Neuroscience, 2004
- Glutamate, Dopamine, and SchizophreniaAnnals of the New York Academy of Sciences, 2003
- Plastic Control of Striatal Glutamatergic Transmission by Ensemble Actions of Several Neurotransmitters and Targets for Drugs of AbuseAnnals of the New York Academy of Sciences, 2003
- Localization of ionotropic glutamate receptors in caudate-putamen and nucleus accumbens septi of rat brain: Comparison of NMDA, AMPA, and kainate receptorsSynapse, 1998
- An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtypeNeuroscience Letters, 1996
- An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtypeNeuroscience Letters, 1996
- Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's diseaseTrends in Neurosciences, 1990
- Presence of Kynurenic Acid in the Mammalian BrainJournal of Neurochemistry, 1988