Dose‐response in epidemiology—age and time aspects

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Abstract
The influence of age and time factors on the dose‐response relationship will depend on the parameter of risk estimation; e.g., excess risk may increase with age at exposure while relative risk may decrease with age at exposure. “Time since onset of exposure” and “time since last exposure” are probably more important factors to consider than “age at exposure” in most types of occupational epidemiology.