Heparin precipitable fraction of plasma (HPF) is not influenced by the presence of fibrin monomers

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Abstract
The heparin precipitable fraction of plasma consists mainly of fibrinogen and fibronectin. In our work with HPF in patients with acute myocardial infarction we observed variations in the amount of precipitate that could not be accounted for by corresponding variations in the plasma content of fibrinogen and fibronectin. To see whether the presence/absence of fibrin monomers in plasma could be of importance for this variation in HPF, we have: added fibrin des‐AA monomers to normal and patient plasmas incubated normal and patient plasmas with insolubilized reptilase until a strongly positive ethanol gelation test could be demonstrated examined a potential correlation between a positive ethanol gelation test and HPF in a patient material. From the results of the above investigations, we could conclude that the presence of fibrin monomers (presence of soluble fibrin) is of no importance for the variations observed in the HPF‐phenomenon.