A monoclonal antibody-defined membrane antigen complex is required for neutrophil-neutrophil aggregation
Open Access
- 1 June 1985
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 65 (6) , 1553-1556
- https://doi.org/10.1182/blood.v65.6.1553.bloodjournal6561553
Abstract
We examined the aggregation responses of normal neutrophils treated with the murine monoclonal antibody (MoAb) 60.3. Addition of MoAb 60.3 to normal neutrophils produced dose-dependent inhibition of neutrophil aggregation in response to phorbol myristate acetate, zymosan-activated plasma, and N-formyl-methionylleucylphenylalanine. We conclude that the membrane glycoprotein complex recognized by MoAb 60.3--designated CDw18- -is required for neutrophil-neutrophil aggregation in vitro.This publication has 0 references indexed in Scilit: