Tir Tyrosine Phosphorylation and Pedestal Formation Are Delayed in Enteropathogenic Escherichia coli sepZ ::Tn phoA Mutant 30-5-1(3)
- 1 January 2001
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (1) , 559-563
- https://doi.org/10.1128/iai.69.1.559-563.2001
Abstract
Enteropathogenic Escherichia coli (EPEC) strain 30-5-1(3) has been reported to form attaching and effacing (A/E) lesions without Tir tyrosine phosphorylation. In this study, we show that 30-5-1(3), which has a transposon insertion within the sepZ gene, forms wild-type A/E lesions including Tir tyrosine phosphorylation, but at a slower rate. A/E lesion formation by 30-5-1(3) occurs without detectable secretion of Tir or other EPEC Esp secreted proteins.Keywords
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