THYROTROPIN-RELEASING-HORMONE - NEUROGENESIS OF ACTIONS IN THE PENTOBARBITAL NARCOTIZED RAT

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 212  (2) , 203-210
Abstract
Possible neuroanatomical substrates mediating some of the effects seen with thyrotropin-releasing hormone (TRH) in the pentobarbital (PB) narcotized rat were examined. This was accomplished by microinjecting picomole concentrations of TRH into 20 different brain sites. The behavioral effects examined were the capacity of TRH to antagonize PB-induced narcosis and hypothermia and TRH-induced shaking behavior. Microinjection of TRH into the septum was significantly more effective in the reversal of PB narcosis than any other site examined. The temperature and shaking response were evoked with approximately equal efficacy by TRH microinjection into a number of brain sites; including the preoptic/anterior hypothalamus, medial thalamus, thalamic periventricular gray, interpeduncular nucleus and locus ceruleus. Apparently, the septal region is the site of action for TRH reversal of PB narcosis and the septohippocampal system involved. The neurogenesis of the shaking response is similar to that of the temperature response and that this differs from the neurogenesis of the analeptic response.