Monoalkylidene Derivatives of Meldrum's Acid
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 10 (9) , 661-665
- https://doi.org/10.1080/00397918008065647
Abstract
We were in need of several aliphatic monoalkylidene derivatives of Meldrum's acid (1) for use in conjunction with a current synthetic problem. Implementation of base1,2 or Lewis acid3 initiated Knoevenagel conditions were found to be unsatisfactory, in our hands, due to the intercedence of subsequent Michael addition of Meldrum's acid to the desired product. We reasoned, therefore, that a method should be employed which generates the alkylidene derivative in the absence of Meldrum's acid.Keywords
This publication has 7 references indexed in Scilit:
- An efficient conversion of ketones to .alpha.,.beta.-unsaturated ketonesThe Journal of Organic Chemistry, 1978
- Verbesserte variante der knoevenagel-kondensation mit TiCl4/THF/pyridin(I). Alkyliden- und Arylidenmalonester bei 0–25°C.Tetrahedron Letters, 1970
- Alkylidenmeldrumsäuren aus geradkettigen aldehydenTetrahedron Letters, 1969
- Zur Kenntnis cyclischer Acylale, 6. Mitt.Monatshefte für Chemie / Chemical Monthly, 1964
- Über Säureamidacetale, Harnstoffacetale und LactamacetaleEuropean Journal of Organic Chemistry, 1961
- The Structure of Meldrum's Supposed β-Lactonic AcidJournal of the American Chemical Society, 1948
- Über eine Bildungsweise ungesättigter Ketone aus substituierten Amino‐methylenketonenBerichte der deutschen chemischen Gesellschaft (A and B Series), 1931