Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats
- 1 August 1980
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 18 (2) , 346-348
- https://doi.org/10.1128/aac.18.2.346
Abstract
The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days were compared in Fischer rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.Keywords
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