Bleomycin, and antitumor antibiotic: improved microbiological assay and tissue distribution studies in normal mice.

  • 1 October 1971
    • journal article
    • Vol. 22  (4) , 564-6
Abstract
A microbiological assay was developed for bleomycin, an antitumor antibiotic reported to be active in human trials. The assay bacterium was a strain of Escherichia coli which is resistant to ethionine. Studies revealed relatively high concentrations of bleomycin in the blood and urine of mice after a single dose, < 0.33 ld(10), injected intraperitoneally.