Two New Antigens of Human IgG, “Non b0” and “Non b1,” Related to the Gm System

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Abstract
A hidden rheumatoid factor, reacting with a human IgG antigen, called “non b”, present on all Gm(b) negative IgG3 proteins, and also on all IgG1 and IgG2 proteins, but not on IgG3 Gm(b) or IgG4, was revealed by gel filtration. A similar specificity was demonstrated in two properly absorbed baboon antisera against human myeloma proteins. The “non b” antigen could be further divided into “non b1,” detected by the rheumatoid anti-“non b” and by one of the baboon antisera, and “non b0” detected by the other hetero-antiserum. The “non b0” antigen was present on the pFc′ and Fc′ fragments of human IgG, whereas “non b1” was found to be present on Fc outside pFc. This subdivision of “non b” was further supported by experiments with selected IgG3 myeloma proteins and anti-Rh antibodies.′ The “non b0” and “non b1” antigens reflect the close relationship among the IgG subclass proteins and may be valuable markers in studying the evolution of the IgG subclasses.

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