Antibiotics from basidiomycetes. VII. Crinipellin, a new antibiotic from the basidiomycetous fungus Crinipellis stipitaria (Fr.) Pat.

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Abstract
A crystalline antibiotic named crinipellin was isolated from submerged cultures of the basidiomycete C. stipitaria, strain no. 7612. High resolution mass spectrometry yielded the formula C22H28O5. The antibiotic is most active against gram-positive bacteria, although yeasts and filamentous fungi are affected to a lesser extent. Crinipellin exhibits high in vitro inhibitory activity against the ascitic form of Ehrlich [mouse ascites] carcinoma. The incorporation of precursors of DNA, RNA, and protein syntheses in Ehrlich carcinoma (and in Bacillus brevis) cells was completely inhibited at 5(10) .mu.g/ml. In B. brevis the inhibition of the incorporation of uridine was due to an interference by crinipellin with the transport of the precursor into the cells.