ELECTROMAGNETIC DETERMINATION OF REGIONAL BLOOD FLOW IN UNANESTHETIZED ANIMALS

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Abstract
A method is described for the determination of regional blood flow in normal animals through intact blood vessels left in their normal place and unexposed. The measuring device and procedure is such that drugs (such as heparin or anesthetics) are not needed, the animal being as nearly as possible in its normal state. Inserted instruments are suitable for chronic implantation. The relation between blood flow and instrument reading is linear and independent of variations in physical factors like temperature, viscosity, velocity profile (laminar or turbulent flow), etc. The response of the instrument to velocity changes is instantaneous and frequent calibrations of the instrument unnecessary. Examples illustrate the possibility of studying the effects of physiological and psychological stimuli as well as of pharmacological agents upon essentially normal conscious animals. The next step in this work will consist of improving the apparatus and procedure so as to make it adaptable to the measurement of blood flow in human beings and in animals in any accessible blood vessel of sufficiently large diameter.

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