Generalized Pustular Psoriasis in a Child
- 4 November 1961
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 178 (5) , 511-513
- https://doi.org/10.1001/jama.1961.73040440025014d
Abstract
A RECENT series of 25,000 dermatological patients examined over a period of years1revealed 1,625 patients, or 6.5%, to have psoriasis. Of the latter, only 3 patients were diagnosed to have the rare variant of generalized pustular psoriasis. Generalized pustular psoriasis was in fact first described in 1910 by von Zumbusch.2Later, Schaeffer3and Ebert4further contributed to its understanding. This variant, occurring in psoriatic patients, is characterized by an explosive generalized eruption, marked by high fever and toxicity, without evident precipitating cause. The dermatitis progresses from early discrete and sterile pustules to shallow subcorneal layers of pus, then to dry, brownish crusts, and finally to a generalized exfoliation. The disease is cyclic in nature, associated with complete clearance of the disseminated pustular phase and unexplained reexacerbations. Reports of occasional fatalities are recognized.1,5Möslein,6in an extensive review of the literature up to 1958,Keywords
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