Investigation of the Hormonal Axis Hypothalamus-Pituitary-Gonads in 20 Dialyzed Men

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Abstract
Male patients [20] suffering from end-stage chronic renal failure and maintained on hemodialysis were investigated for pituitary response to GnRH [gonadotropin-releasing hormone, gonadoliberin]. The GnRH-Test was performed simultaneously with hemodialysis; however, hemodialysis was started 60 min after GnRH injection. Basal LH [lutropin] and FSH [follitropin] values were significantly higher (P < 0.0001 and 0.005, respectively) than the normal range, while basal testosterone values were in the subnormal range or depressed (P < 0.0001). Poststimulatory LH values were significantly lower (P < 0.01) than normal and - other than normal - did not decline within 180 min, following GnRH injection (P < 0.001). The same pattern was seen for FSH; no statistical significance could be secured. Testosterone was elevated 30 min. after stimulation with GnRH (P < 0.001).