Ineffectiveness of Pyridoxine (B6) to Alter Secretion of Growth Hormone and Prolactin and Absence of Therapeutic Effects on Galactorrhea-Amenorrhea Syndromes

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Abstract
The acute effect of pyridoxine (B6) on serum GH [growth hormone] and PRL [prolactin] levels and its chronic effects on galactorrhea in 9 subjects (group I, n = 4, idiopathic galactorrhea with normal PRL levels and normal menses; Group II, n = 5, galactorrhea-amenorrhea with increased PRL levels) were studied. Pyridoxine did not acutely alter GH or PRL levels. There was no decrease in galactorrhea, no resumption of menses and no decrease in PRL following 2 months of B6 therapy. Bromocriptine was effective in suppressing galactorrhea and restoring normal menses in group II subjects and remains the therapy of choice for this purpose.

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