The role of tobacco in penile carcinoma

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Abstract
Objective To study the role of tobacco in squamous cell carcinoma of the penis. Subjects and methods The use of tobacco in the form of cigarettes, chewing tobacco and snuff was studied in a total of 503 patients and age‐matched controls. Results By multivariate analysis, a significant association was found between smoking (P= 0.002) or chewing tobacco (P< 0.001) and the use of snuff (P= 0.004) in patients with penile carcinoma as compared with controls. A dose‐response relationship was observed for both smoking and chewing. Conclusions The use of tobacco is a significant risk factor for penile carcinoma, and the use of more than one form of tobacco increases this risk.