SELECTIVE ALKYLATION OF NUCLEIC-ACIDS BY CARCINOGENS MAY CAUSE MISCODING IN DNA - A THEORETICAL-STUDY
- 1 January 1982
- journal article
- research article
- Vol. 6 (1) , 31-35
Abstract
The CNDO/II method was used to study the pairing abilities of various alkylated nucleic acids. On the basis of these results, a mechanism for mutation (carcinogenesis) is proposed. Calculations suggest that O-(6) alkylated guanine and/or O-(4) alkylated thymine could cause miscoding during the replication of DNA.This publication has 4 references indexed in Scilit:
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