ISOLATION AND CHARACTERIZATION OF RAT HY POTH AL AM IC SOM ATOST AT IN-14
- 1 May 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 108 (5) , 2008-2010
- https://doi.org/10.1210/endo-108-5-2008
Abstract
A peptide with somatostatin-like immuno- and bioactivity has been isolated from 1165 rat hypothalami by using antisomatostatin affinity chromatography, gel filtration and reverse-phase high-performance liquid chromatography. The isolated peptide is indistinguishable from synthetic somatostatin-14 with respect to chromatographic properties and amino acid composition. We therefore propose that rat hypothalamic somatostatin-14 is identical in structure to somatostatin-14 found in other species.Keywords
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