Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy
- 1 April 1979
- journal article
- research article
- Published by Springer Nature in Journal of Neurocytology
- Vol. 8 (2) , 197-213
- https://doi.org/10.1007/bf01175561
Abstract
This report describes the retrograde degeneration affecting olfactory sensory neurons of rats after severance of their axons and illustrates the reconstitution of new neurons originating from stem cells located at the base of the olfactory neuroepithelium. Degeneration of the mature, axotomized neurons, signalled by an increased electron density of their cytoplasmic matrix and by the appearance of lipofuscin-like granules, can be detected in the neuroepithelium as early as 24 h after surgery and becomes conspicuous between the second and the third day. Degenerating neurons can be observed in decreasing number up to the tenth post-operative day. They are removed by macrophages which invade the epithelium. The reconstitution of new neurons begins to occur after eight days, when the stem cells undergo vigorous mitotic activity and differentiate into neurons. The morphology of the reconstituted neurons has been described in detail at different stages of their maturation. After 30 days, the olfactory epithelium appears similar to controls. On the basis of both morphological (in rats) and autoradiographic (in mice) observations, the basal cells have been recognized as stem cells of the olfactory neurons.Keywords
This publication has 19 references indexed in Scilit:
- Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Morphological aspects of differentiation and structural organization of the olfactory sensory neuronsJournal of Neurocytology, 1979
- Denervation in the primary olfactory pathway of mice. IV. Biochemical and morphological evidence for neuronal replacement following nerve sectionBrain Research, 1977
- Structural and functional evidence of plasticity in the central nervous systemExperimental Neurology, 1975
- History of central nervous system regeneration researchExperimental Neurology, 1975
- Ultrastructural study of mouse olfactory epithelium following destruction by ZnSO4 and its subsequent regenerationJournal of Anatomy, 1975
- Producing and interpreting experimental olfactory deficitsPhysiology & Behavior, 1974
- Cell dynamics in the olfactory mucosaTissue and Cell, 1973
- NEURONAL REGENERATION IN FROG OLFACTORY SYSTEMThe Journal of cell biology, 1973
- Regeneration of rabbit olfactory epitheliumJournal of Anatomy, 1971
- THE PROJECTION OF THE OLFACTORY EPITHELIUM ON THE OLFACTORY BULB IN THE RABBITJournal of Neurology, Neurosurgery & Psychiatry, 1951