Effects of Quinidine on Serum Digoxin Concentration

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Abstract
Results of studies of 15 adult cardiology patients placed on quinidine therapy after their serum digoxin concentrations were stabilized showed significantly increased digoxin concentrations. The average digoxin concentration before quinidine therapy was 0.75 .+-. 0.28 ng/ml and after 4 days of quinidine therapy was 1.41 .+-. 0.43 ng/ml. During this period, the renal clearance of digoxin decreased from 53.4 .+-. 21 ml/min .cntdot. 1.73 m to 35.3 .+-. 12.6 ml/min .cntdot. 1.73 m. No significant decrease in creatinine clearance occurred. A significant correlation was found between the individual rise in serum digoxin concentrations and the rise in serum quinidine concentrations. Serum digoxin concentration should be monitored closely for at least the 1st 4 days of quinidine therapy.